creb1 inhibitor 66615 Search Results


creb1 inhibitor  (MedChemExpress)
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MedChemExpress creb1 inhibitor
Fig. 2. The effect of prenatal NaF exposure on fetal weight and <t>p-Creb1/BDNF/TrkB</t> pathway in fetal. The fetal brain weight (A), body weight (B) and fetal brain weight/body weight ratio (C) (n = 22). Total Creb1, p-Creb1, pro-BDNF, TrkB, SYN and PSD95 protein abundance in the fetal hippocampus (D) (n = 6). CD stands for the control, * P＜0.05, ** P＜0.01, *** P＜0.001, **** P＜0.0001, the NaF group vs. the control group. Values were calculated as mean ± SD.
Creb1 Inhibitor, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Fig. 2. The effect of prenatal NaF exposure on fetal weight and p-Creb1/BDNF/TrkB pathway in fetal. The fetal brain weight (A), body weight (B) and fetal brain weight/body weight ratio (C) (n = 22). Total Creb1, p-Creb1, pro-BDNF, TrkB, SYN and PSD95 protein abundance in the fetal hippocampus (D) (n = 6). CD stands for the control, * P＜0.05, ** P＜0.01, *** P＜0.001, **** P＜0.0001, the NaF group vs. the control group. Values were calculated as mean ± SD.

Journal: Ecotoxicology and environmental safety

Article Title: Gestational exposure to fluoride impairs cognition in C57 BL/6 J male offspring mice via the p-Creb1-BDNF-TrkB signaling pathway.

doi: 10.1016/j.ecoenv.2022.113682

Figure Lengend Snippet: Fig. 2. The effect of prenatal NaF exposure on fetal weight and p-Creb1/BDNF/TrkB pathway in fetal. The fetal brain weight (A), body weight (B) and fetal brain weight/body weight ratio (C) (n = 22). Total Creb1, p-Creb1, pro-BDNF, TrkB, SYN and PSD95 protein abundance in the fetal hippocampus (D) (n = 6). CD stands for the control, * P＜0.05, ** P＜0.01, *** P＜0.001, **** P＜0.0001, the NaF group vs. the control group. Values were calculated as mean ± SD.

Article Snippet: The sodium fluoride (#7681–49–4, St. Louis, Mo, USA) was purchased from Sigma-Aldrich, and 66615 (CREB1 inhibitor, #HY-101120, Monmouth Junction, NJ, USA) was purchased from Med Chem Express.

Techniques: Quantitative Proteomics, Control

Fig. 5. Prenatal NaF exposure reduced dendritic spine density and synaptic protein expression linked to p-Creb1/BDNF/TrkB signaling disruption in male offspring mice. The hippocampus neuron nuclei (A), synaptic clefts and postsynaptic densities (B) (n = 3). Synaptic clefts and postsynaptic densities in two groups (C, D). Total Creb1, p-Creb1, pro-BDNF, TrkB, SYN and PSD95 protein abundance in two groups (E) (n = 6). CD stands for the control, * P＜0.05, ** P＜0.01, **** P＜0.0001, the NaF group vs. the control group. Values were calculated as mean ± SD.

Journal: Ecotoxicology and environmental safety

Article Title: Gestational exposure to fluoride impairs cognition in C57 BL/6 J male offspring mice via the p-Creb1-BDNF-TrkB signaling pathway.

doi: 10.1016/j.ecoenv.2022.113682

Figure Lengend Snippet: Fig. 5. Prenatal NaF exposure reduced dendritic spine density and synaptic protein expression linked to p-Creb1/BDNF/TrkB signaling disruption in male offspring mice. The hippocampus neuron nuclei (A), synaptic clefts and postsynaptic densities (B) (n = 3). Synaptic clefts and postsynaptic densities in two groups (C, D). Total Creb1, p-Creb1, pro-BDNF, TrkB, SYN and PSD95 protein abundance in two groups (E) (n = 6). CD stands for the control, * P＜0.05, ** P＜0.01, **** P＜0.0001, the NaF group vs. the control group. Values were calculated as mean ± SD.

Article Snippet: The sodium fluoride (#7681–49–4, St. Louis, Mo, USA) was purchased from Sigma-Aldrich, and 66615 (CREB1 inhibitor, #HY-101120, Monmouth Junction, NJ, USA) was purchased from Med Chem Express.

Techniques: Expressing, Disruption, Quantitative Proteomics, Control

Fig. 6. NaF-induced disruption of the p-Creb1-BDNF-TrkB pathway and cytoskeleton abnormalities in PC12 cells. The CCK8 test (A) (n = 3). The cytoskeleton staining with rhodamine phalloidin labeling (B) (n = 3). Total Creb1, p-Creb1, pro-BDNF, TrkB, SYN and PSD95 protein abundance (C) (n = 3). * P＜0.05, ** P＜ 0.01 vs. the control group. Values were calculated as mean ± SD.

Journal: Ecotoxicology and environmental safety

Article Title: Gestational exposure to fluoride impairs cognition in C57 BL/6 J male offspring mice via the p-Creb1-BDNF-TrkB signaling pathway.

doi: 10.1016/j.ecoenv.2022.113682

Figure Lengend Snippet: Fig. 6. NaF-induced disruption of the p-Creb1-BDNF-TrkB pathway and cytoskeleton abnormalities in PC12 cells. The CCK8 test (A) (n = 3). The cytoskeleton staining with rhodamine phalloidin labeling (B) (n = 3). Total Creb1, p-Creb1, pro-BDNF, TrkB, SYN and PSD95 protein abundance (C) (n = 3). * P＜0.05, ** P＜ 0.01 vs. the control group. Values were calculated as mean ± SD.

Article Snippet: The sodium fluoride (#7681–49–4, St. Louis, Mo, USA) was purchased from Sigma-Aldrich, and 66615 (CREB1 inhibitor, #HY-101120, Monmouth Junction, NJ, USA) was purchased from Med Chem Express.

Techniques: Disruption, Staining, Labeling, Quantitative Proteomics, Control